PP1 dephosphorylates TGFBR1

Stable Identifier
R-HSA-178178
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PP1 dephosphorylates TGF-beta receptor-1 (TGFBR1), thereby inhibiting TGF-beta signaling. It has not been precisely examined whether PP1 dephosphorylates all TGFBR1 serine and threonine residues phosphorylated by TGFBR2 (Shi et al. 2004). This was inferred from experiments that used a recombinant mouse Smad7 and recombinant human TGFBR1, TGFBR2 and PP1.

Literature References
PubMed ID Title Journal Year
14718519 GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Shi, W, Sun, C, He, B, Xiong, W, Shi, X, Yao, D, Cao, X

J Cell Biol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created