Ppp3 complex dephosphorylates DARPP-32 on T34

Stable Identifier
R-RNO-201760
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ppp3 complex dephosphorylates DARPP-32 on T34
The human event is deduced on the basis of experiments in rats (Desdouits et al. 1995).
Literature References
PubMed ID Title Journal Year
7708705 Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin

Desdouits, F, Siciliano, JC, Greengard, P, Girault, JA

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Catalyst Activity

protein serine/threonine phosphatase activity of Calcineurin complex [cytosol]

Physical Entity
Calcineurin complex [cytosol] (Rattus norvegicus)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2007-09-20)
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