Reactome | NRPE is a substrate for Abca4

NRPE is a substrate for Abca4

Stable Identifier

R-BTA-2466767

Type

Reaction [transition]

Species

Bos taurus

Compartment

cytosol, photoreceptor disc membrane

ReviewStatus

5/5

General

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Bovine studies (Beharry et al. 2004) have indicated NRPE to be the preferred substrate for Abca4 (Abcr, rim protein, RmP) (Illing et al. 1997), which acts an inward-directed retinoid flippase and facilitates the transfer of NRPE to the cytoplasmic side of the disc membrane. This transfer is essential to avoid build up of potentially toxic retinoid intermediates which are implicated in many retinal degenerative diseases (see review Tsybovsky et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15471866	N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR) Beharry, S, Zhong, M, Molday, RS	J. Biol. Chem.	2004
9092582	The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily Illing, M, Molday, LL, Molday, RS	J. Biol. Chem.	1997

Participants

Input

Output

Catalyst Activity

retinol transmembrane transporter activity of Abca4 [photoreceptor disc membrane]

Physical Entity

Abca4 [photoreceptor disc membrane] (Bos taurus)

Activity

retinol transmembrane transporter activity (GO:0034632)

Orthologous Events

ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol (Homo sapiens)

Created

Jassal, B (2012-09-12)

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