Endocytosis of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-421007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Endocytosis of Ca impermeable AMPA receptors
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GluR2 containing AMPA receptors are constitutively recycled between the endosome membrane and the plasma membrane. GRIP and PICK compete for the binding to the C tail of GluR2. Once the GluR2 containing AMPA receptors are in the plasmamembrane, phosphorylation of GluR2 at S880 by PKC causes disruption of GRIP interaction, but not PICK interaction which facilitates internalization of GluR2 containing AMPA receptors into endosomes.
Literature References
PubMed ID Title Journal Year
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking

Lu, W, Ziff, EB

Neuron 2005
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Input
Output
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as an event of
Catalyst Activity

calcium,diacylglycerol-dependent serine/threonine kinase activity of Activated conventional protein kinase C [plasma membrane]

Physical Entity
Activated conventional protein kinase C [plasma membrane] (Homo sapiens)
Activity
calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698)
Orthologous Events
Endocytosis of Ca impermeable AMPA receptors (Bos taurus)
Endocytosis of Ca impermeable AMPA receptors (Drosophila melanogaster)
Endocytosis of Ca impermeable AMPA receptors (Gallus gallus)
Endocytosis of Ca impermeable AMPA receptors (Mus musculus)
Endocytosis of Ca impermeable AMPA receptors (Rattus norvegicus)
Endocytosis of Ca impermeable AMPA receptors (Sus scrofa)
Authored
Mahajan, SS  (2008-01-14)
Reviewed
Ziff, EB  (2009-05-15)
Created
Mahajan, SS  (2009-05-15)
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