Endocytosis of Ca impermeable AMPA receptors

Stable Identifier
R-HSA-421007
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GluR2 containing AMPA receptors are constitutively recycled between the endosome membrane and the plasma membrane. GRIP and PICK compete for the binding to the C tail of GluR2. Once the GluR2 containing AMPA receptors are in the plasmamembrane, phosphorylation of GluR2 at S880 by PKC causes disruption of GRIP interaction, but not PICK interaction which facilitates internalization of GluR2 containing AMPA receptors into endosomes.

Literature References
PubMed ID Title Journal Year
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking

Lu, W, Ziff, EB

Neuron 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium-dependent protein kinase C activity of Activated conventional protein kinase C [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created