ABCB11 transports bile salts from cytosol to extracellular region

Stable Identifier
R-HSA-193362
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
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A molecule of glycocholate, glycochenodeoxycholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCB11 (bile salt export pump). In the body, this reaction mediates the release of bile salts from the liver cells into the bile (Kullak-Ublick et al. 2004); the role of ABCB11 in the reaction is confirmed by the observed failure of bile salt export in patients in whom the transporter is defective (Noe et al. 2005).

Literature References
PubMed ID Title Journal Year
12404240 Functional expression of the canalicular bile salt export pump of human liver

Noe, J, Stieger, B, Meier, PJ

Gastroenterology 2002
12404239 The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

Byrne, JA, Strautnieks, SS, Mieli-Vergani, G, Higgins, CF, Linton, KJ, Thompson, RJ

Gastroenterology 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase-coupled bile acid transmembrane transporter activity of ABCB11 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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