Reactome | ABCB11 transports bile salts from cytosol to extracellular region

ABCB11 transports bile salts from cytosol to extracellular region

Stable Identifier

R-HSA-193362

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transport (efflux) of bile salts by ABCB11 (bile salt export pump)

ReviewStatus

5/5

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ABCB11 transports bile salts from cytosol to extracellular region

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A molecule of glycocholate, glycochenodeoxycholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCB11 (bile salt export pump). In the body, this reaction mediates the release of bile salts from the liver cells into the bile (Kullak-Ublick et al. 2004); the role of ABCB11 in the reaction is confirmed by the observed failure of bile salt export in patients in whom the transporter is defective (Noe et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
12404239	The human bile salt export pump: characterization of substrate specificity and identification of inhibitors Higgins, CF, Byrne, JA, Linton, KJ, Strautnieks, SS, Thompson, RJ, Mieli-Vergani, G	Gastroenterology	2002
12404240	Functional expression of the canalicular bile salt export pump of human liver Noe, J, Meier, PJ, Stieger, B	Gastroenterology	2002