ABCB11 transports bile salts from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
Transport (efflux) of bile salts by ABCB11 (bile salt export pump)
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A molecule of glycocholate, glycochenodeoxycholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCB11 (bile salt export pump). In the body, this reaction mediates the release of bile salts from the liver cells into the bile (Kullak-Ublick et al. 2004); the role of ABCB11 in the reaction is confirmed by the observed failure of bile salt export in patients in whom the transporter is defective (Noe et al. 2005).

Literature References
PubMed ID Title Journal Year
12404239 The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

Higgins, CF, Byrne, JA, Linton, KJ, Strautnieks, SS, Thompson, RJ, Mieli-Vergani, G

Gastroenterology 2002
12404240 Functional expression of the canalicular bile salt export pump of human liver

Noe, J, Meier, PJ, Stieger, B

Gastroenterology 2002
Catalyst Activity

ABC-type bile acid transporter activity of ABCB11 [plasma membrane]

Orthologous Events
Cross References
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