NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

Stable Identifier
R-HSA-2395876
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT15)
ReviewStatus
5/5
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NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NUDT15 (MTH2) catalyzes the reaction of 8-oxo-dGDP and water to form 8-oxo-dGMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT15 has not been established but is assumed to be cytosolic like NUDT1.
Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D, Kamiya, H

J. Biol. Chem. 2012
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Catalyst Activity

8-oxo-dGDP phosphatase activity of NUDT15 [cytosol]

Physical Entity
NUDT15 [cytosol] (Homo sapiens)
Activity
8-oxo-dGDP phosphatase activity (GO:0044715)
Orthologous Events
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Bos taurus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Canis familiaris)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Gallus gallus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Mus musculus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Rattus norvegicus)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Sus scrofa)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-07-06)
Reviewed
Ito, R  (2012-10-05)
Created
D'Eustachio, P  (2012-07-03)
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