PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane

Stable Identifier
R-HSA-1676164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the plasma membrane, type I and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and (INPP4B) (Norris et al. 1997) dephosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to phosphatidylinositol 3-phosphate (PI3P).

Literature References
PubMed ID Title Journal Year
15716355 The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

Luff, S, Majerus, PW, Kisseleva, MV, Rowe, T, Zhang, XM, Tiganis, T, Munday, AD, Ivetac, I, Mitchell, CA, Whisstock, JC

Mol Biol Cell 2005
9295334 The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family

Atkins, RC, Majerus, PW, Norris, FA

J Biol Chem 1997
7608176 The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase

Auethavekiat, V, Majerus, PW, Norris, FA

J Biol Chem 1995
Participants
Participates
Catalyst Activity

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity of INPP4A/B [cytosol]

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