Reactome | PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane

PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane

Stable Identifier

R-HSA-1676164

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane

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At the plasma membrane, type I and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4A) (Norris et al. 1995, Ivetac et al. 2005) and (INPP4B) (Norris et al. 1997) dephosphorylate phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to phosphatidylinositol 3-phosphate (PI3P).

Literature References

PubMed ID	Title	Journal	Year
7608176	The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase Norris, FA, Auethavekiat, V, Majerus, PW	J Biol Chem	1995
15716355	The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane Ivetac, I, Munday, AD, Kisseleva, MV, Zhang, XM, Luff, S, Tiganis, T, Whisstock, JC, Rowe, T, Majerus, PW, Mitchell, CA	Mol Biol Cell	2005
9295334	The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family Norris, FA, Atkins, RC, Majerus, PW	J Biol Chem	1997