Reactome | PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

Stable Identifier

R-HSA-1675836

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane

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At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P).

Literature References

PubMed ID	Title	Journal	Year
18093523	The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Mani, M, Lee, SY, Lucast, L, Cremona, O, Di Paolo, G, De Camilli, P, Ryan, TA	Neuron	2007
11084340	Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis Malecz, N, McCabe, PC, Spaargaren, C, Qiu, R, Chuang, Y, Symons, M	Curr Biol	2000
10224048	SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases Guo, S, Stolz, LE, Lemrow, SM, York, JD	J Biol Chem	1999