Reactome | PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

Stable Identifier

R-HSA-1675949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

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At the plasma membrane, phosphatidylinositol 5-phosphatases dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The phosphatidylinositol 5-phosphatases involved are: inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP (Ijuin et al. 2000, Gurung et al. 2003), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP (Gurung et al. 2003, Mochizuki & Takenawa 1999), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1 (Drayer et al. 1995, Kavanaugh et al. 1996, Dunant et al. 2000), and phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2 (Habib et al. 1998, Wisniewski et al. 1999, Pesesse et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
9660833	Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein Habib, T, Hejna, JA, Moses, RE, Decker, SJ	J Biol Chem	1998
10753883	Identification and characterization of a novel inositol polyphosphate 5-phosphatase Ijuin, T, Mochizuki, Y, Fukami, K, Funaki, M, Asano, T, Takenawa, T	J Biol Chem	2000
8769125	Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase Drayer, AL, Pesesse, X, De Smedt, F, Woscholski, R, Parker, P, Erneux, C	Biochem Biophys Res Commun	1996
11349134	The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells Pesesse, X, Dewaste, V, De Smedt, F, Laffargue, M, Giuriato, S, Moreau, C, Payrastre, B, Erneux, C	J Biol Chem	2001
8723348	Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 Kavanaugh, WM, Pot, DA, Chin, SM, Deuter-Reinhard, M, Jefferson, AB, Norris, FA, Masiarz, FR, Cousens, LS, Majerus, PW, Williams, LT	Curr Biol	1996
10593988	Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles Mochizuki, Y, Takenawa, T	J Biol Chem	1999
12536145	Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation Gurung, R, Tan, A, Ooms, LM, McGrath, MJ, Huysmans, RD, Munday, AD, Prescott, M, Whisstock, JC, Mitchell, CA	J Biol Chem	2003
10194451	A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells Wisniewski, D, Strife, A, Swendeman, S, Erdjument-Bromage, H, Geromanos, S, Kavanaugh, WM, Tempst, P, Clarkson, B	Blood	1999
10822173	The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells Dunant, NM, Wisniewski, D, Strife, A, Clarkson, B, Resh, MD	Cell Signal	2000