PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane

Stable Identifier
R-HSA-1675949
Type
Reaction
Species
Homo sapiens
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At the plasma membrane, phosphatidylinositol 5-phosphatases dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The phosphatidylinositol 5-phosphatases involved are: inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP (Ijuin et al. 2000, Gurung et al. 2003), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP (Gurung et al. 2003, Mochizuki & Takenawa 1999), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1 (Drayer et al. 1995, Kavanaugh et al. 1996, Dunant et al. 2000), and phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2 (Habib et al. 1998, Wisniewski et al. 1999, Pesesse et al. 2001).

Literature References
PubMed ID Title Journal Year
10753883 Identification and characterization of a novel inositol polyphosphate 5-phosphatase

Funaki, M, Ijuin, T, Fukami, K, Takenawa, T, Asano, T, Mochizuki, Y

J Biol Chem 2000
9660833 Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein

Moses, RE, Hejna, JA, Habib, T, Decker, SJ

J Biol Chem 1998
8769125 Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase

Woscholski, R, Parker, P, Pesesse, X, Erneux, C, Drayer, AL, De Smedt, F

Biochem Biophys Res Commun 1996
11349134 The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells

Payrastre, B, Laffargue, M, Pesesse, X, Erneux, C, Giuriato, S, Dewaste, V, De Smedt, F, Moreau, C

J Biol Chem 2001
8723348 Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

Kavanaugh, WM, Jefferson, AB, Masiarz, FR, Pot, DA, Majerus, PW, Deuter-Reinhard, M, Chin, SM, Cousens, LS, Norris, FA, Williams, LT

Curr Biol 1996
10593988 Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles

Takenawa, T, Mochizuki, Y

J Biol Chem 1999
12536145 Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation

Tan, A, Prescott, M, Munday, AD, Mitchell, CA, McGrath, MJ, Gurung, R, Whisstock, JC, Huysmans, RD, Ooms, LM

J Biol Chem 2003
10194451 A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells

Kavanaugh, WM, Strife, A, Wisniewski, D, Clarkson, B, Tempst, P, Swendeman, S, Geromanos, S, Erdjument-Bromage, H

Blood 1999
10822173 The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells

Strife, A, Wisniewski, D, Clarkson, B, Resh, MD, Dunant, NM

Cell Signal 2000
Participants
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Catalyst Activity

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity of INPP5(2) [cytosol]

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