Trehalose-6-phosphate is hydrolyzed to trehalose

Stable Identifier
R-MTU-868608
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
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Hydrolysis of trehalose phosphate, catalyzed by OtsB2, gives trehalose. The enzyme needs magnesium for its activity. A second homologue, OtsB1 is non-functional (De Smet et al, 2000; Edavana et al, 2004).

Literature References
PubMed ID Title Journal Year
15158675 Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis

Edavana, VK, Pastuszak, I, Carroll, JD, Thampi, P, Abraham, EC, Elbein, AD

Arch Biochem Biophys 2004
10658666 Three pathways for trehalose biosynthesis in mycobacteria

De Smet, KA, Weston, A, Brown, IN, Young, DB, Robertson, BD

Microbiology 2000
Participants
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Catalyst Activity

trehalose-phosphatase activity of OtsB-Mg2+ [cytosol]

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