abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Stable Identifier
R-HSA-2161506
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ABCG2-mediated abacavir efflux
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General
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ATP-binding cassette sub-family G member 2 (ABCG2), associated with the plasma membrane, mediates the ATP-dependent efflux of abacavir (Doyle et al. 1998). The active form of ABCG2 is a homodimer stabilized by an interchain disulfide bond (Wakabayashi et al. 2007). The abacavir specificity of the human ABCG2 transporter is inferred from studies of the corresponding mouse protein (Pan et al. 2007).

Literature References
PubMed ID Title Journal Year
17437964 Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine

Pan, G, Giri, N, Elmquist, WF

Drug Metab Dispos 2007
17686774 Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein

Wakabayashi, K, Nakagawa, H, Tamura, A, Koshiba, S, Hoshijima, K, Komada, M, Ishikawa, T

J Biol Chem 2007
9861027 A multidrug resistance transporter from human MCF-7 breast cancer cells

Doyle, LA, Yang, W, Abruzzo, LV, Krogmann, T, Gao, Y, Rishi, AK, Ross, DD

Proc Natl Acad Sci U S A 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase-coupled xenobiotic transmembrane transporter activity of ABCG2 tetramer [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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