abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Stable Identifier
Reaction [transition]
Homo sapiens
ABCG2-mediated abacavir efflux
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATP-binding cassette sub-family G member 2 (ABCG2), associated with the plasma membrane, mediates the ATP-dependent efflux of abacavir (Doyle et al. 1998). The active form of ABCG2 is a homodimer stabilized by an interchain disulfide bond (Wakabayashi et al. 2007). The abacavir specificity of the human ABCG2 transporter is inferred from studies of the corresponding mouse protein (Pan et al. 2007).

Literature References
PubMed ID Title Journal Year
17686774 Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein

Nakagawa, H, Komada, M, Tamura, A, Ishikawa, T, Koshiba, S, Hoshijima, K, Wakabayashi, K

J Biol Chem 2007
17437964 Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine

Giri, N, Elmquist, WF, Pan, G

Drug Metab Dispos 2007
9861027 A multidrug resistance transporter from human MCF-7 breast cancer cells

Yang, W, Ross, DD, Doyle, LA, Krogmann, T, Gao, Y, Rishi, AK, Abruzzo, LV

Proc Natl Acad Sci U S A 1998
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCG2 tetramer [plasma membrane]

Inferred From
Cite Us!