Reactome | PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)

PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)

Stable Identifier

R-HSA-9865167

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)

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PTPN1 (PTP1B) interacts with Annexin A2 (Ye et al. 2021) and dephosphorylates tyrosine-24 of Annexin A2 (ANXA2) (Zhang et al. 2020) in response to turbulent flow across endothelial cells. Serine-26 of ANXA2 remains phosphorylated (Zhang et al. 2020). Activation of the mechanosensitive cation channel PIEZO1 is required for dephosphorylation of ANXA2 (Zhang et al. 2020). PTPN1 may be activated by calcium-dependent cleavage by calpain (Frangioni et al. 1993, de Jong et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
32673515	Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation Zhang, C, Zhou, T, Chen, Z, Yan, M, Li, B, Lv, H, Wang, C, Xiang, S, Shi, L, Zhu, Y, Ai, D	Circ Res	2020