MYO9B inactivates RHOA

Stable Identifier
R-HSA-8985594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MYO9B (MYR5) is a RHO GAP protein that stimulates RHOA GTPase activity, resulting in hydrolysis of RHOA bound GTP to GDP, and conversion of the active form of RHOA, RHOA:GTP, to the inactive form, RHOA:GDP (Post et al. 1998, Graf et al. 2000, Kong et al. 2015). MYO9B does not act on CDC42 and RAC1. The GAP activity of MYO9B is inhibited by binding to ROBO1 receptor activated by SLIT2 (Kong et al. 2015).

Literature References
PubMed ID Title Journal Year
11207612 Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri

Graf, B, Bähler, M, Hilpelä, P, Böwe, C, Adam, T

Cell. Microbiol. 2000
9490638 Human myosin-IXb is a mechanochemically active motor and a GAP for rho

Post, PL, Bokoch, GM, Mooseker, MS

J. Cell. Sci. 1998
26529257 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

Kong, R, Yi, F, Wen, P, Liu, J, Chen, X, Ren, J, Li, X, Shang, Y, Nie, Y, Wu, K, Fan, D, Zhu, L, Feng, W, Wu, JY

J. Clin. Invest. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of MYO9B [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
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Created