Reactome | MYO9B inactivates RHOA

MYO9B inactivates RHOA

Stable Identifier

R-HSA-8985594

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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MYO9B (MYR5) is a RHO GAP protein that stimulates RHOA GTPase activity, resulting in hydrolysis of RHOA bound GTP to GDP, and conversion of the active form of RHOA, RHOA:GTP, to the inactive form, RHOA:GDP (Post et al. 1998, Graf et al. 2000, Kong et al. 2015). MYO9B does not act on CDC42 and RAC1. The GAP activity of MYO9B is inhibited by binding to ROBO1 receptor activated by SLIT2 (Kong et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
9490638	Human myosin-IXb is a mechanochemically active motor and a GAP for rho Post, PL, Bokoch, GM, Mooseker, MS	J. Cell. Sci.	1998
11207612	Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri Böwe, C, Bähler, M, Hilpelä, P, Adam, T, Graf, B	Cell. Microbiol.	2000
26529257	Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression Nie, Y, Li, X, Zhu, L, Fan, D, Wen, P, Liu, J, Yi, F, Kong, R, Wu, JY, Wu, K, Chen, X, Shang, Y, Feng, W, Ren, J	J. Clin. Invest.	2015