MYO9B inactivates RHOA

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MYO9B (MYR5) is a RHO GAP protein that stimulates RHOA GTPase activity, resulting in hydrolysis of RHOA bound GTP to GDP, and conversion of the active form of RHOA, RHOA:GTP, to the inactive form, RHOA:GDP (Post et al. 1998, Graf et al. 2000, Kong et al. 2015). MYO9B does not act on CDC42 and RAC1. The GAP activity of MYO9B is inhibited by binding to ROBO1 receptor activated by SLIT2 (Kong et al. 2015).
Literature References
PubMed ID Title Journal Year
9490638 Human myosin-IXb is a mechanochemically active motor and a GAP for rho

Post, PL, Bokoch, GM, Mooseker, MS

J. Cell. Sci. 1998
11207612 Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri

Böwe, C, Bähler, M, Hilpelä, P, Adam, T, Graf, B

Cell. Microbiol. 2000
26529257 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

Nie, Y, Li, X, Zhu, L, Fan, D, Wen, P, Liu, J, Yi, F, Kong, R, Wu, JY, Wu, K, Chen, X, Shang, Y, Feng, W, Ren, J

J. Clin. Invest. 2015
Catalyst Activity

GTPase activator activity of MYO9B [cytosol]

This event is regulated
Orthologous Events
Cite Us!