Dephosphorylation of JAK1 by SHP1

Stable Identifier
R-HSA-997314
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Dephosphorylation of JAK1 by SHP1
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SHP1 directly associates with and dephosphorylates JAK1/2.
Literature References
PubMed ID Title Journal Year
18508557 Protein tyrosine phosphatases in the JAK/STAT pathway

Xu, D, Qu, CK

Front Biosci 2008
8943354 Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

Jiao, H, Platanias, LC, Yi, T, Yang, W, Tabrizi, M, Berrada, K

Mol Cell Biol 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN6 [cytosol]

Physical Entity
PTPN6 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
Dephosphorylation of JAK1 by SHP1 (Bos taurus)
Dephosphorylation of JAK1 by SHP1 (Canis familiaris)
Dephosphorylation of JAK1 by SHP1 (Gallus gallus)
Dephosphorylation of JAK1 by SHP1 (Mus musculus)
Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
Dephosphorylation of JAK1 by SHP1 (Sus scrofa)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-11-09)
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