Reactome | PA is dephosphorylated to DAG by LPIN

PA is dephosphorylated to DAG by LPIN

Stable Identifier

R-HSA-1483203

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the endoplasmic reticulum (ER) membrane, phosphatidate phosphatase 1-3 (LPIN) dephosphorylates phosphatidic acid (PA) to form diacylglycerol (DAG) (Grimsey et al. 2008, Donkor et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17158099	Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns Donkor, J, Sariahmetoglu, M, Dewald, J, Brindley, DN, Reue, K	J Biol Chem	2007
18694939	Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2 Grimsey, N, Han, GS, O'Hara, L, Rochford, JJ, Carman, GM, Siniossoglou, S	J Biol Chem	2008