Cytosolic DUSPs dephosphorylate MAPKs

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Cytosolic MAPKs are dephosphorylated by the MAPK-specific class II DUSPs 6,7 and 9, but may also be dephosphorylated by cytosolic forms of class III DUSPs 8, 10 and 16, which preferentially dephosphorylate p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kandoh and Nishida, 2007).

Literature References
PubMed ID Title Journal Year
17208316 Regulation of MAP kinases by MAP kinase phosphatases

Kondoh, K, Nishida, E

Biochim. Biophys. Acta 2007
20463170 The dual-specificity MAP kinase phosphatases: critical roles in development and cancer

Gimond, C, Pag├Ęs, G, Bermudez, O

Am. J. Physiol., Cell Physiol. 2010
22569528 ERK1/2 MAP kinases: structure, function, and regulation

Roskoski, R Jr

Pharmacol. Res. 2012
Catalyst Activity

protein tyrosine/serine/threonine phosphatase activity of cytosolic MAPK DUSPs [cytosol]

Orthologous Events
Cite Us!