SeMet is converted to AdoSeMet by MAT

Stable Identifier
R-HSA-2408551
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ATP + H2O + L-selenomethionine => diphosphate + L-adenosylselenomethionine + phosphate
ReviewStatus
5/5
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SeMet is converted to AdoSeMet by MAT
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Methionine adenosyltransferases (MAT multimers) consisting of a S-adenosylmethionine synthase isoform type-1 (MAT1A) homodimer and a MAT1A: S-adenosylmethionine synthase isoform type-2 (MAT2A) heterodimer are responsible for the conversion of selenomethionine (SeMet) and ATP into Se-adenosylselenomethionine (AdoSeMet), orthophosphate (Pi), and diphosphate (PPi) (Kajander et al. 1990).
Literature References
PubMed ID Title Journal Year
2339986 Effects of selenomethionine on cell growth and on S-adenosylmethionine metabolism in cultured malignant cells

Kajander, EO, Harvima, RJ, Kauppinen, L, Akerman, KK, Martikainen, H, Pajula, RL, Kärenlampi, SO

Biochem. J. 1990
Participants
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Output
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as an event of
Catalyst Activity

selenomethionine adenosyltransferase activity of MAT1A multimers [cytosol]

Physical Entity
MAT1A multimers [cytosol] (Homo sapiens)
Activity
selenomethionine adenosyltransferase activity (GO:0098601)
Orthologous Events
SeMet is converted to AdoSeMet by MAT (Bos taurus)
SeMet is converted to AdoSeMet by MAT (Canis familiaris)
SeMet is converted to AdoSeMet by MAT (Danio rerio)
SeMet is converted to AdoSeMet by MAT (Dictyostelium discoideum)
SeMet is converted to AdoSeMet by MAT (Gallus gallus)
SeMet is converted to AdoSeMet by MAT (Mus musculus)
SeMet is converted to AdoSeMet by MAT (Plasmodium falciparum)
SeMet is converted to AdoSeMet by MAT (Rattus norvegicus)
SeMet is converted to AdoSeMet by MAT (Saccharomyces cerevisiae)
SeMet is converted to AdoSeMet by MAT (Schizosaccharomyces pombe)
SeMet is converted to AdoSeMet by MAT (Sus scrofa)
SeMet is converted to AdoSeMet by MAT (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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