G alpha (z) in G alpha (z):RGS complex is inactivated

Stable Identifier
Reaction [transition]
Homo sapiens
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G Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G proteins). Upon activation, GPCRs can replace the GDP with GTP in the alpha subunit of G proteins. GTP binding modifies the conformation of G alpha proteins and activates them. The Regulator of G protein Signalling (RGS) are GTPase Accelerating Proteins (GAPs) that can directly inhibit the G alpha subunit activity. There are at least 25 different types of RGS proteins known. RGS16, RGS17 and RGS20 can bind and stabilize the transition state of Guanine nucleotide binding protein G(z) subunit alpha (GNAZ). Following this, RGS exerts its GAP activity on GNAZ and facilitates the hydrolyses GTP to GDP. This inactivates GNAZ and terminates downstream signalling (Neubig & Siderovski 2002, Kach et al. 2012, Goto K et al. 2017). GNAZ inhibits adenylyl cyclase and interacts with Rap1GAP to attenuate Rap1 signaling.

Literature References
PubMed ID Title Journal Year
28502923 G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review]

Goto, K, Doi, M, Wang, T, Kunisue, S, Murai, I, Okamura, H

Endocr. J. 2017
12120503 Regulators of G-protein signalling as new central nervous system drug targets

Neubig, RR, Siderovski, DP

Nat Rev Drug Discov 2002
18434541 Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits

Soundararajan, M, Willard, FS, Kimple, AJ, Turnbull, AP, Ball, LJ, Schoch, GA, Gileadi, C, Fedorov, OY, Dowler, EF, Higman, VA, Hutsell, SQ, Sundström, M, Doyle, DA, Siderovski, DP

Proc. Natl. Acad. Sci. U.S.A. 2008
Catalyst Activity

GTPase activity of G alpha (z):GTP:RGS16,17,20 [plasma membrane]

Orthologous Events
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