Reactome | PPM1L dephosphorylates multiphospho-CERT1-2

PPM1L dephosphorylates multiphospho-CERT1-2

Stable Identifier

R-HSA-429730

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

O-phospho-L-seryl/threonyl-(protein) + H2O => L-seryl/threonyl-(protein) + phosphate

ReviewStatus

5/5

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PPM1L dephosphorylates multiphospho-CERT1-2

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Multiphospho-CERT (ceramide transfer protein) associates with the complex of VAPA/B (VAMP-associated proteins A or B) and PPM1L (protein phosphatase 1-like) in the endoplasmic reticulum membrane (Kawano et al. 2006; Saito et al. 2008; Kumagai & Hanada 2019), enabling PPM1L to catalyze the dephosphorylation of the multiphospho-CERT complex component (Saito et al. 2008; Kumagai & Hanada 2019). This dephosphorylation restores CERT’s ability to bind and transport ceramide.

Literature References

PubMed ID	Title	Journal	Year
18165232	Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes Saito, S, Matsui, H, Kawano, M, Kumagai, K, Tomishige, N, Hanada, K, Echigo, S, Tamura, S, Kobayashi, T	J Biol Chem	2008
31254361	Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites Kumagai, K, Hanada, K	FEBS Lett	2019