PPM1L dephosphorylates multiphospho-CERT1-2

Stable Identifier
R-HSA-429730
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate
ReviewStatus
5/5
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PPM1L (protein phosphatase 1-like) catalyzes the dephosphorylation of multiphospho-“CERT” (ceramide transfer protein) that is complexed with it in the endoplasmic reticulum membrane (Saito et al. 2008; reviewed by Kumagai & Hanada, 2019). This reinstates binding of ceramide to and its transport by CERT.

Literature References
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of p-S,S132,T-CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane]

Orthologous Events
Authored
Reviewed
Created
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