ABCG2 tetramer transports heme from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
Export of heme to the blood by ABCG2
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Heme is utilised as a prosthetic group in the production of hemoproteins inside cells. However, when intracellular heme accumulation occurs, heme is able to exert its pro-oxidant and cytotoxic action. The amount of free heme must be tightly controlled to maintain cellular homeostasis and avoid pathological conditions (Chiabrando et al. 2014). The tetrameric efflux pump ATP-binding cassette sub-family G member 2 (ABCG2) (Xu et al. 2004) can relieve cells from toxic heme concentrations even against a concentration gradient. It is expressed in placenta, liver, and small intestine (Krishnamurthy et al. 2004, Doyle & Ross 2003, Zhang et al. 2003).

Literature References
PubMed ID Title Journal Year
12958161 The expression and functional characterization of ABCG2 in brain endothelial cells and vessels

Zhang, W, Mojsilovic-Petrovic, J, Andrade, MF, Zhang, H, Ball, M, Stanimirovic, DB

FASEB J 2003
15001581 Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2

Xu, J, Liu, Y, Yang, Y, Bates, S, Zhang, JT

J. Biol. Chem. 2004
15044468 The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

Krishnamurthy, P, Ross, DD, Nakanishi, T, Bailey-Dell, K, Zhou, S, Mercer, KE, Sarkadi, B, Sorrentino, BP, Schuetz, JD

J Biol Chem 2004
14576842 Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

Doyle, LA, Ross, DD

Oncogene 2003
Participant Of
Catalyst Activity
Catalyst Activity
ATPase-coupled heme transmembrane transporter activity of ABCG2 tetramer [plasma membrane]
Physical Entity
Orthologous Events
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