ABCG2 tetramer transports heme from cytosol to extracellular region

Stable Identifier
R-HSA-917979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Export of heme to the blood by ABCG2
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ABCG2 tetramer transports heme from cytosol to extracellular region
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Heme is utilised as a prosthetic group in the production of hemoproteins inside cells. However, when intracellular heme accumulation occurs, heme is able to exert its pro-oxidant and cytotoxic action. The amount of free heme must be tightly controlled to maintain cellular homeostasis and avoid pathological conditions (Chiabrando et al. 2014). The tetrameric efflux pump ATP-binding cassette sub-family G member 2 (ABCG2) (Xu et al. 2004) can relieve cells from toxic heme concentrations even against a concentration gradient. It is expressed in placenta, liver, and small intestine (Krishnamurthy et al. 2004, Doyle & Ross 2003, Zhang et al. 2003).

Literature References
PubMed ID Title Journal Year
12958161 The expression and functional characterization of ABCG2 in brain endothelial cells and vessels

Zhang, W, Mojsilovic-Petrovic, J, Andrade, MF, Zhang, H, Ball, M, Stanimirovic, DB

FASEB J 2003
15001581 Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2

Xu, J, Liu, Y, Yang, Y, Bates, S, Zhang, JT

J. Biol. Chem. 2004
15044468 The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

Krishnamurthy, P, Ross, DD, Nakanishi, T, Bailey-Dell, K, Zhou, S, Mercer, KE, Sarkadi, B, Sorrentino, BP, Schuetz, JD

J Biol Chem 2004
14576842 Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

Doyle, LA, Ross, DD

Oncogene 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
heme transporter activity of ABCG2 tetramer [plasma membrane]
Physical Entity
ABCG2 tetramer [plasma membrane]
Activity
heme transporter activity (0015232)
Orthologous Events
ABCG2 tetramer transports heme from cytosol to extracellular region (Canis familiaris)
ABCG2 tetramer transports heme from cytosol to extracellular region (Danio rerio)
ABCG2 tetramer transports heme from cytosol to extracellular region (Dictyostelium discoideum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Gallus gallus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Mus musculus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Plasmodium falciparum)
ABCG2 tetramer transports heme from cytosol to extracellular region (Rattus norvegicus)
ABCG2 tetramer transports heme from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCG2 tetramer transports heme from cytosol to extracellular region (Sus scrofa)
ABCG2 tetramer transports heme from cytosol to extracellular region (Xenopus tropicalis)
Authored
Stephan, R  (2010-07-07)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)