Reactome | ABCG2 tetramer transports heme from cytosol to extracellular region

ABCG2 tetramer transports heme from cytosol to extracellular region

Stable Identifier

R-HSA-917979

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate, Export of heme to the blood by ABCG2

ReviewStatus

5/5

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ABCG2 tetramer transports heme from cytosol to extracellular region

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Heme is utilised as a prosthetic group in the production of hemoproteins inside cells. However, when intracellular heme accumulation occurs, heme is able to exert its pro-oxidant and cytotoxic action. The amount of free heme must be tightly controlled to maintain cellular homeostasis and avoid pathological conditions (Chiabrando et al. 2014). The tetrameric efflux pump ATP-binding cassette sub-family G member 2 (ABCG2) (Xu et al. 2004) can relieve cells from toxic heme concentrations even against a concentration gradient. It is expressed in placenta, liver, and small intestine (Krishnamurthy et al. 2004, Doyle & Ross 2003, Zhang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
15001581	Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2 Liu, Y, Xu, J, Bates, S, Zhang, JT, Yang, Y	J. Biol. Chem.	2004
12958161	The expression and functional characterization of ABCG2 in brain endothelial cells and vessels Stanimirovic, DB, Zhang, H, Mojsilovic-Petrovic, J, Andrade, MF, Ball, M, Zhang, W	FASEB J	2003
15044468	The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme Zhou, S, Sarkadi, B, Ross, DD, Sorrentino, BP, Nakanishi, T, Bailey-Dell, K, Krishnamurthy, P, Schuetz, JD, Mercer, KE	J Biol Chem	2004
14576842	Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) Ross, DD, Doyle, LA	Oncogene	2003