Reactome | PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

Stable Identifier

R-HSA-74242

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)

ReviewStatus

5/5

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PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

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Cytosolic purine nucleoside phosphorylase (PNP) trimer catalyzes the reversible reaction of inosine or deoxyinosine with orthophosphate to form hypoxanthine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). While PNP is active with either nucleotide in vitro, levels of deoxyinosine are normally low in vivo, limiting the extent of this reaction. PNP deficiency in vivo is associated with accumulation of inosine and deoxyinosine and leads to immunodeficiency (Williams et al. 1987).

Literature References

PubMed ID	Title	Journal	Year
3029074	A human purine nucleoside phosphorylase deficiency caused by a single base change Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW	J Biol Chem	1987
6771276	Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides Hutton, JJ, Wiginton, DA, Coleman, MS	J Biol Chem	1980
2104852	Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution Cook, WJ, Habash, J, Greenhough, TJ, Babu, YS, Carter, DC, Parks, Jr, RE, Rule, SA, Bugg, CE, Stoeckler, JD, Chen, SF, Ealick, SE, Helliwell, JR	J Biol Chem	1990