Reactome | SLC34A3 cotransports Pi, 2Na+

SLC34A3 cotransports Pi, 2Na+

Stable Identifier

R-HSA-427645

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Electroneutral Na+/Pi cotransport

ReviewStatus

5/5

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SLC34A3 is almost exclusively expressed in the kidney and encodes the Na+/Pi cotransporter NaPi-IIc (Segawa et al. 2002). The protein is located at apical membranes of proximal tubules. It cotransports two Na+ ions with every Pi (electroneutral transport). Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (Bergwitz et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16358214	SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis Bergwitz, C, Roslin, NM, Tieder, M, Loredo-Osti, JC, Bastepe, M, Abu-Zahra, H, Frappier, D, Burkett, K, Carpenter, TO, Anderson, D, Garabedian, M, Sermet, I, Fujiwara, TM, Morgan, K, Tenenhouse, HS, Juppner, H	Am J Hum Genet	2006
11880379	Growth-related renal type II Na/Pi cotransporter Segawa, H, Kaneko, I, Takahashi, A, Kuwahata, M, Ito, M, Ohkido, I, Tatsumi, S, Miyamoto, K	J Biol Chem	2002