SLC34A3 cotransports Pi, 2Na+

Stable Identifier
Reaction [transition]
Homo sapiens
Electroneutral Na+/Pi cotransport
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SLC34A3 is almost exclusively expressed in the kidney and encodes the Na+/Pi cotransporter NaPi-IIc (Segawa et al. 2002). The protein is located at apical membranes of proximal tubules. It cotransports two Na+ ions with every Pi (electroneutral transport). Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) (Bergwitz et al. 2006).

Literature References
PubMed ID Title Journal Year
11880379 Growth-related renal type II Na/Pi cotransporter

Segawa, H, Kaneko, I, Takahashi, A, Kuwahata, M, Ito, M, Ohkido, I, Tatsumi, S, Miyamoto, K

J Biol Chem 2002
16358214 SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis

Bergwitz, C, Roslin, NM, Tieder, M, Loredo-Osti, JC, Bastepe, M, Abu-Zahra, H, Frappier, D, Burkett, K, Carpenter, TO, Anderson, D, Garabedian, M, Sermet, I, Fujiwara, TM, Morgan, K, Tenenhouse, HS, Juppner, H

Am J Hum Genet 2006
Catalyst Activity

sodium:phosphate symporter activity of SLC34A3 [plasma membrane]

Orthologous Events
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