Reactome | AKT1 dephosphorylation by PP2A-B56-beta,gamma

AKT1 dephosphorylation by PP2A-B56-beta,gamma

Stable Identifier

R-HSA-6811504

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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AKT1 dephosphorylation by PP2A-B56-beta,gamma

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The protein phosphatase 2A (PP2A) complex containing a regulatory subunit B56 beta (PPP2R5B) or B56 gamma (PPP2R5C) dephosphorylates activated AKT1 on threonine residue T308 and serine residue S473, thus halting PI3K/AKT signaling (Rocher et al. 2007). Phosphatidylinositol-5-phosphate (PI5P) negatively regulates PP2A-mediated dephosphorylation of AKT1 by promoting, through an unknown mechanism, an inhibitory phosphorylation on tyrosine residue Y307 (Chen et al. 1992) of the catalytic subunit of PP2A (Ramel et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
1325671	Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation Chen, J, Martin, BL, Brautigan, DL	Science	1992
19576174	PtdIns5P protects Akt from dephosphorylation through PP2A inhibition Ramel, D, Lagarrigue, F, Dupuis-Coronas, S, Chicanne, G, Leslie, N, Gaits-Iacovoni, F, Payrastre, B, Tronchère, H	Biochem. Biophys. Res. Commun.	2009
17200115	Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity Rocher, G, Letourneux, C, Lenormand, P, Porteu, F	J. Biol. Chem.	2007