Reactome | PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol

PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol

Stable Identifier

R-HSA-1855166

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol

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Diphosphoinositol polyphosphate phosphohydrolase 2, also known as nucleoside diphosphate-linked moiety X motif 4 (NUDT4), dephosphorylates diphospho- tetrakisphosphate (PP-IP4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5). The products made are: inositol 5-diphospho-1,3,4,6-tetrakisphosphate (5-PP-IP4); inositol 1-diphospho-3,4,5,6-tetrakisphosphate (1-PP-IP4); and inositol 3-diphospho-1,4,5,6-tetrakisphosphate (3-PP-IP4).

The following lists the above protein with its corresponding literature references: NUDT4 (Saiardi et al. 2001, Saiardi et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10827188	The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis Saiardi, A, Caffrey, JJ, Snyder, SH, Shears, SB	J Biol Chem	2000
11502751	Identification and characterization of a novel inositol hexakisphosphate kinase Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH	J Biol Chem	2001