Reactome | PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane

PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane

Stable Identifier

R-HSA-1676177

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane

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At the plasma membrane, Synaptojanin-1 (SYNJ1) and -2 (SYNJ2), inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). SYNJ1/2 both have an N-terminal Sac1-like domain, a central 5-phosphatase domain and a C-terminal proline-rich segment, with this latter part being the most divergent part of the protein sequence.

The following lists the above proteins with their corresponding literature references: SYNJ1 (Johenning et al. 2004, Haffner et al. 1997, Guo et al. 1999, Mani et al. 2007), SYNJ2 (Malecz et al. 2000), INPP5K (Injuin et al. 2000, Gurung et al. 2003), and INPP5J (Gurung et al. 2003, Mochizuki & Takenawa 1999).

Literature References

PubMed ID	Title	Journal	Year
18093523	The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Mani, M, Lee, SY, Lucast, L, Cremona, O, Di Paolo, G, De Camilli, P, Ryan, TA	Neuron	2007
10753883	Identification and characterization of a novel inositol polyphosphate 5-phosphatase Ijuin, T, Mochizuki, Y, Fukami, K, Funaki, M, Asano, T, Takenawa, T	J Biol Chem	2000
15080793	InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1 Johenning, FW, Wenk, MR, Uhlén, P, Degray, B, Lee, E, De Camilli, P, Ehrlich, BE	Biochem J	2004
10593988	Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles Mochizuki, Y, Takenawa, T	J Biol Chem	1999
12536145	Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation Gurung, R, Tan, A, Ooms, LM, McGrath, MJ, Huysmans, RD, Munday, AD, Prescott, M, Whisstock, JC, Mitchell, CA	J Biol Chem	2003
11084340	Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis Malecz, N, McCabe, PC, Spaargaren, C, Qiu, R, Chuang, Y, Symons, M	Curr Biol	2000
10224048	SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases Guo, S, Stolz, LE, Lemrow, SM, York, JD	J Biol Chem	1999
9428629	Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15 Haffner, C, Takei, K, Chen, H, Ringstad, N, Hudson, A, Butler, MH, Salcini, AE, Di Fiore, PP, De Camilli, P	FEBS Lett	1997