5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate

Stable Identifier
R-GGA-419144
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic PFAS (phosphoribosylformylglycinamidine synthase) catalyzes the reaction of 5'-phosphoribosylformylglycinamide (FGAR), L-glutamine, ATP, and water to form 5'-phosphoribosylformylglycinamidine (FGAM), L-glutamate, ADP, and orthophosphate. The enzyme has been purified to homogeneity from chicken liver and characterized biochemically, but its amino acid sequence remains unknown so it cannot be associated with a specific chicken gene. The enzyme is active as a monomer, though catalytically active multimers have been observed (Mizobuchi and Buchanan 1968; Frere et al. 1971).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphoribosylformylglycinamidine synthase activity of PFAS [cytosol]

Physical Entity
PFAS [cytosol] (Gallus gallus)
Activity
phosphoribosylformylglycinamidine synthase activity (GO:0004642)
Authored
D'Eustachio, P  (2009-04-29)
Created
D'Eustachio, P  (2009-04-29)
Cite Us!