5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate

Stable Identifier
R-GGA-419144
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
ReviewStatus
5/5
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5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + ADP + orthophosphate
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Cytosolic PFAS (phosphoribosylformylglycinamidine synthase) catalyzes the reaction of 5'-phosphoribosylformylglycinamide (FGAR), L-glutamine, ATP, and water to form 5'-phosphoribosylformylglycinamidine (FGAM), L-glutamate, ADP, and orthophosphate. The enzyme has been purified to homogeneity from chicken liver and characterized biochemically, but its amino acid sequence remains unknown so it cannot be associated with a specific chicken gene. The enzyme is active as a monomer, though catalytically active multimers have been observed (Mizobuchi and Buchanan 1968; Frere et al. 1971).

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Catalyst Activity

phosphoribosylformylglycinamidine synthase activity of PFAS [cytosol]

Physical Entity
PFAS [cytosol] (Gallus gallus)
Activity
phosphoribosylformylglycinamidine synthase activity (GO:0004642)
Authored
D'Eustachio, P  (2009-04-29)
Created
D'Eustachio, P  (2009-04-29)
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