Dephosphorylation of PAG by SHP2

Stable Identifier
R-HSA-177926
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Dephosphorylation of PAG by SHP2
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Dephosphorylation of CBP/PAG negatively regulates the recruitment of the Src inhibiting kinase, Csk. Src is not negatively regulated by phosphorylation by Csk.
Literature References
PubMed ID Title Journal Year
14967142 Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

Zhang, SQ, Yang, W, Kontaridis, MI, Bivona, TG, Wen, G, Araki, T, Luo, J, Thompson, JA, Schraven, BL, Philips, MR, Neel, BG

Mol. Cell 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
Activity
non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)
Orthologous Events
Dephosphorylation of PAG by SHP2 (Bos taurus)
Dephosphorylation of PAG by SHP2 (Canis familiaris)
Dephosphorylation of PAG by SHP2 (Gallus gallus)
Dephosphorylation of PAG by SHP2 (Mus musculus)
Dephosphorylation of PAG by SHP2 (Rattus norvegicus)
Dephosphorylation of PAG by SHP2 (Sus scrofa)
Dephosphorylation of PAG by SHP2 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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