PTPRJ dephosphorylates MET

Stable Identifier
R-HSA-6807008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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PTPRJ dephosphorylates MET
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PTPRJ (DEP1) protein tyrosine phosphatase dephosphorylates MET tyrosine residue Y1349. As Y1349 is a GAB1 docking site, PTPRJ-mediated dephosphorylation of MET prevents GAB1 binding to MET and activation of MET-initiated GAB1 signaling. PTPRJ can also dephosphorylate MET at Y1365, which is of unknown importance (Palka et al. 2003).

Literature References
PubMed ID Title Journal Year
12475979 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1

Palka, HL, Park, M, Tonks, NK

J. Biol. Chem. 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPRJ [plasma membrane]
Physical Entity
PTPRJ [plasma membrane]
Activity
protein tyrosine phosphatase activity (0004725)
Orthologous Events
PTPRJ dephosphorylates MET (Danio rerio)
PTPRJ dephosphorylates MET (Gallus gallus)
PTPRJ dephosphorylates MET (Mus musculus)
PTPRJ dephosphorylates MET (Rattus norvegicus)
PTPRJ dephosphorylates MET (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2015-10-28)
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