PTPRJ (DEP1) protein tyrosine phosphatase dephosphorylates MET tyrosine residue Y1349. As Y1349 is a GAB1 docking site, PTPRJ-mediated dephosphorylation of MET prevents GAB1 binding to MET and activation of MET-initiated GAB1 signaling. PTPRJ can also dephosphorylate MET at Y1365, which is of unknown importance (Palka et al. 2003).
Tonks, NK, Park, M, Palka, HL
protein tyrosine phosphatase activity of PTPRJ [plasma membrane]
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