RHOT2 hydrolyzes GTP

Stable Identifier
R-HSA-9018826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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RHOT2 hydrolyzes GTP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RHOT2 (Miro2) possesses a high intrinsic GTPase activity and does not require a GTPase activator protein (GAP) to hydrolyze GTP (Peters et al. 2018).
Literature References
PubMed ID Title Journal Year
30513825 Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism

Lakey, JH, Kay, L, Soundararajan, M, Eswaran, J, Peters, DT

Int J Mol Sci 2018
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Output
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Catalyst Activity

GTPase activity of RHOT2:GTP [mitochondrial outer membrane]

Physical Entity
RHOT2:GTP [mitochondrial outer membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
RHOT2 hydrolyzes GTP (Bos taurus)
RHOT2 hydrolyzes GTP (Caenorhabditis elegans)
RHOT2 hydrolyzes GTP (Danio rerio)
RHOT2 hydrolyzes GTP (Dictyostelium discoideum)
RHOT2 hydrolyzes GTP (Drosophila melanogaster)
RHOT2 hydrolyzes GTP (Gallus gallus)
RHOT2 hydrolyzes GTP (Mus musculus)
RHOT2 hydrolyzes GTP (Rattus norvegicus)
RHOT2 hydrolyzes GTP (Saccharomyces cerevisiae)
RHOT2 hydrolyzes GTP (Schizosaccharomyces pombe)
RHOT2 hydrolyzes GTP (Sus scrofa)
RHOT2 hydrolyzes GTP (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-07-14)
Reviewed
Schrader, M  (2021-02-09)
Castro, IG  (2021-02-09)
Created
Orlic-Milacic, M  (2017-09-05)
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