Reactome | PP6 dephosphorylates SEC24

PP6 dephosphorylates SEC24

Stable Identifier

R-HSA-5694421

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)

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PP6 dephosphorylates released coat proteins including SEC24, SEC31 and SEC23, allowing them to recycle for further rounds of vesicle budding from the ER (Lord et al, 2011; Bhandari et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
23864707	Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits Bhandari, D, Zhang, J, Menon, S, Lord, C, Chen, S, Helm, JR, Thorsen, K, Corbett, KD, Hay, JC, Ferro-Novick, S	Mol. Biol. Cell	2013
21532587	Sequential interactions with Sec23 control the direction of vesicle traffic Lord, C, Bhandari, D, Menon, S, Ghassemian, M, Nycz, D, Hay, J, Ghosh, P, Ferro-Novick, S	Nature	2011