PP6 dephosphorylates SEC24

Stable Identifier
R-HSA-5694421
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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PP6 dephosphorylates released coat proteins including SEC24, SEC31 and SEC23, allowing them to recycle for further rounds of vesicle budding from the ER (Lord et al, 2011; Bhandari et al, 2013).

Literature References
PubMed ID Title Journal Year
23864707 Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits

Bhandari, D, Ferro-Novick, S, Zhang, J, Menon, S, Thorsen, K, Helm, JR, Corbett, KD, Chen, S, Lord, C, Hay, JC

Mol. Biol. Cell 2013
21532587 Sequential interactions with Sec23 control the direction of vesicle traffic

Ghassemian, M, Ghosh, P, Bhandari, D, Ferro-Novick, S, Menon, S, Nycz, D, Lord, C, Hay, J

Nature 2011
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of PP6 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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