Reactome | PP6 dephosphorylates SEC24

PP6 dephosphorylates SEC24

Stable Identifier

R-HSA-5694421

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PP6 dephosphorylates released coat proteins including SEC24, SEC31 and SEC23, allowing them to recycle for further rounds of vesicle budding from the ER (Lord et al, 2011; Bhandari et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
21532587	Sequential interactions with Sec23 control the direction of vesicle traffic Lord, C, Bhandari, D, Menon, S, Ghassemian, M, Nycz, D, Hay, J, Ghosh, P, Ferro-Novick, S	Nature	2011
23864707	Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits Bhandari, D, Zhang, J, Menon, S, Lord, C, Chen, S, Helm, JR, Thorsen, K, Corbett, KD, Hay, JC, Ferro-Novick, S	Mol. Biol. Cell	2013