PP6 dephosphorylates SEC24

Stable Identifier
R-HSA-5694421
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PP6 dephosphorylates SEC24
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PP6 dephosphorylates released coat proteins including SEC24, SEC31 and SEC23, allowing them to recycle for further rounds of vesicle budding from the ER (Lord et al, 2011; Bhandari et al, 2013).

Literature References
PubMed ID Title Journal Year
21532587 Sequential interactions with Sec23 control the direction of vesicle traffic

Lord, C, Bhandari, D, Menon, S, Ghassemian, M, Nycz, D, Hay, J, Ghosh, P, Ferro-Novick, S

Nature 2011
23864707 Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits

Bhandari, D, Zhang, J, Menon, S, Lord, C, Chen, S, Helm, JR, Thorsen, K, Corbett, KD, Hay, JC, Ferro-Novick, S

Mol. Biol. Cell 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP6 [cytosol]
Physical Entity
PP6 [cytosol]
Activity
protein serine/threonine phosphatase activity (0004722)
Orthologous Events
PP6 dephosphorylates SEC24 (Bos taurus)
PP6 dephosphorylates SEC24 (Canis familiaris)
PP6 dephosphorylates SEC24 (Danio rerio)
PP6 dephosphorylates SEC24 (Gallus gallus)
PP6 dephosphorylates SEC24 (Mus musculus)
PP6 dephosphorylates SEC24 (Rattus norvegicus)
PP6 dephosphorylates SEC24 (Saccharomyces cerevisiae)
PP6 dephosphorylates SEC24 (Sus scrofa)
PP6 dephosphorylates SEC24 (Xenopus tropicalis)
Authored
Rothfels, K  (2015-03-16)
Reviewed
Gillespie, ME  (2015-08-18)
Created
Rothfels, K  (2015-05-21)