PP6 dephosphorylates SEC24

Stable Identifier
R-HSA-5694421
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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PP6 dephosphorylates released coat proteins including SEC24, SEC31 and SEC23, allowing them to recycle for further rounds of vesicle budding from the ER (Lord et al, 2011; Bhandari et al, 2013).

Literature References
PubMed ID Title Journal Year
21532587 Sequential interactions with Sec23 control the direction of vesicle traffic

Lord, C, Bhandari, D, Menon, S, Ghassemian, M, Nycz, D, Hay, J, Ghosh, P, Ferro-Novick, S

Nature 2011
23864707 Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits

Bhandari, D, Zhang, J, Menon, S, Lord, C, Chen, S, Helm, JR, Thorsen, K, Corbett, KD, Hay, JC, Ferro-Novick, S

Mol. Biol. Cell 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP6 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created