Reactome | PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

Stable Identifier

R-HSA-1675988

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

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At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka Synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007, Johenning et al. 2004) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 4-phosphate (PI4P) phosphatidylinositol (PI). The SAC1 domains of SYNJ1 and SYNJ2 demonstrate 4-phosphatase activity.

Literature References

PubMed ID	Title	Journal	Year
15080793	InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1 Johenning, FW, Wenk, MR, Uhlén, P, Degray, B, Lee, E, De Camilli, P, Ehrlich, BE	Biochem J	2004
18093523	The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Mani, M, Lee, SY, Lucast, L, Cremona, O, Di Paolo, G, De Camilli, P, Ryan, TA	Neuron	2007
11084340	Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis Malecz, N, McCabe, PC, Spaargaren, C, Qiu, R, Chuang, Y, Symons, M	Curr Biol	2000
10224048	SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases Guo, S, Stolz, LE, Lemrow, SM, York, JD	J Biol Chem	1999