PI4P is dephosphorylated to PI by SYNJ at the plasma membrane

Stable Identifier
Homo sapiens
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At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka Synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007, Johenning et al. 2004) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 4-phosphate (PI4P) phosphatidylinositol (PI). The SAC1 domains of SYNJ1 and SYNJ2 demonstrate 4-phosphatase activity.

Literature References
PubMed ID Title Journal Year
18093523 The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

Ryan, TA, Cremona, O, Di Paolo, G, Mani, M, Lucast, L, De Camilli, P, Lee, SY

Neuron 2007
15080793 InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1

Lee, E, Ehrlich, BE, Uhlén, P, Johenning, FW, Degray, B, Wenk, MR, De Camilli, P

Biochem J 2004
11084340 Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

Qiu, R, McCabe, PC, Malecz, N, Spaargaren, C, Chuang, Y, Symons, M

Curr Biol 2000
10224048 SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

Lemrow, SM, Guo, S, Stolz, LE, York, JD

J Biol Chem 1999
Catalyst Activity

phosphatidylinositol phosphate 4-phosphatase activity of SYNJs,OCRL [cytosol]

Orthologous Events
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