At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka Synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007, Johenning et al. 2004) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 4-phosphate (PI4P) phosphatidylinositol (PI). The SAC1 domains of SYNJ1 and SYNJ2 demonstrate 4-phosphatase activity.
Ryan, TA, Cremona, O, Di Paolo, G, Mani, M, Lucast, L, De Camilli, P, Lee, SY
Lee, E, Ehrlich, BE, Uhlén, P, Johenning, FW, Degray, B, Wenk, MR, De Camilli, P
Qiu, R, McCabe, PC, Malecz, N, Spaargaren, C, Chuang, Y, Symons, M
Lemrow, SM, Guo, S, Stolz, LE, York, JD
phosphatidylinositol phosphate 4-phosphatase activity of SYNJs,OCRL [cytosol]
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