PTPN22 dephosphorylates ZAP70

Stable Identifier
R-HSA-8855381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PTPN22 dephosphorylates ZAP70
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Protein tyrosine phosphatase PTPN22 (LYP, PEP) dephosphorylates ZAP70 adaptor protein on tyrosine residue Y493, resulting in reduced activation of ZAP70. Dephosphorylation of ZAP70 contributes to PTPN22-mediated downregulation of TCR signaling (Wu et al. 2006).
Literature References
PubMed ID Title Journal Year
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22

Sampang, J, Honigberg, LA, Smith, AM, Clark, JM, Jeffery, D, Buggy, J, Conn, MT, Wu, J, Katrekar, A, Williams, SR, Mortara, K, Tang, J

J. Biol. Chem. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN22 [cytosol]

Physical Entity
PTPN22 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PTPN22 dephosphorylates ZAP70 (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Gallus gallus)
PTPN22 dephosphorylates ZAP70 (Mus musculus)
PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
PTPN22 dephosphorylates ZAP70 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-02-03)
Reviewed
Bottini, N  (2016-05-10)
Stanford, S  (2016-05-10)
Created
Orlic-Milacic, M  (2016-02-04)
Cite Us!