PTPN22 dephosphorylates ZAP70

Stable Identifier
R-HSA-8855381
Type
Reaction
Species
Homo sapiens
Compartment
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Protein tyrosine phosphatase PTPN22 (LYP, PEP) dephosphorylates ZAP70 adaptor protein on tyrosine residue Y493, resulting in reduced activation of ZAP70. Dephosphorylation of ZAP70 contributes to PTPN22-mediated downregulation of TCR signaling (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22

Sampang, J, Honigberg, LA, Smith, AM, Clark, JM, Jeffery, D, Buggy, J, Conn, MT, Wu, J, Katrekar, A, Williams, SR, Mortara, K, Tang, J

J. Biol. Chem. 2006
Participants
Participates
Catalyst Activity

protein tyrosine phosphatase activity of PTPN22 [cytosol]

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