Protein tyrosine phosphatase PTPN22 (LYP, PEP) dephosphorylates ZAP70 adaptor protein on tyrosine residue Y493, resulting in reduced activation of ZAP70. Dephosphorylation of ZAP70 contributes to PTPN22-mediated downregulation of TCR signaling (Wu et al. 2006).
Sampang, J, Honigberg, LA, Smith, AM, Clark, JM, Jeffery, D, Buggy, J, Conn, MT, Wu, J, Katrekar, A, Williams, SR, Mortara, K, Tang, J
protein tyrosine phosphatase activity of PTPN22 [cytosol]
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