PTPN22 dephosphorylates ZAP70

Stable Identifier
R-HSA-8855381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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PTPN22 dephosphorylates ZAP70
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Protein tyrosine phosphatase PTPN22 (LYP, PEP) dephosphorylates ZAP70 adaptor protein on tyrosine residue Y493, resulting in reduced activation of ZAP70. Dephosphorylation of ZAP70 contributes to PTPN22-mediated downregulation of TCR signaling (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22

Wu, J, Katrekar, A, Honigberg, LA, Smith, AM, Conn, MT, Tang, J, Jeffery, D, Mortara, K, Sampang, J, Williams, SR, Buggy, J, Clark, JM

J. Biol. Chem. 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN22 [cytosol]
Physical Entity
PTPN22 [cytosol]
Activity
protein tyrosine phosphatase activity (0004725)
Orthologous Events
PTPN22 dephosphorylates ZAP70 (Bos taurus)
PTPN22 dephosphorylates ZAP70 (Canis familiaris)
PTPN22 dephosphorylates ZAP70 (Mus musculus)
PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
PTPN22 dephosphorylates ZAP70 (Sus scrofa)
PTPN22 dephosphorylates ZAP70 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-02-03)
Reviewed
Stanford, S  (2016-05-10)
Bottini, N  (2016-05-10)
Created
Orlic-Milacic, M  (2016-02-04)