Reactome | glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]

glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]

Stable Identifier

R-HSA-71590

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]

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The phosphorylated PYGL dimer (a form) of glycogen phosphorylase catalyzes the reaction of orthophosphate and glycogen-glycogenin 1 to form D-glucose 1-phosphate and limit dextrin-glycogenin 1. This reaction occurs on the surfaces of cytosolic glycogen granules. Non-phosphorylated PYGL dimers (b form) are catalytically inactive even in the presence of AMP. In the body, this reaction takes place in the liver where its dependence on hormonally stimulated PYGL phosphorylation (and lack of sensitivity to AMP) allow glucose mobilization in response to a demand for glucose from the rest of the body (Newgard et al. 1989; Rath et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10949035	Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core Danley, DE, Mansour, MN, Ammirati, M, Pandit, J, Schulte, GK, LeMotte, PK, Wasilko, DJ, Fennell, KF, Rath, VL, Hynes, TR	Mol Cell	2000
2667896	The family of glycogen phosphorylases: structure and function Hwang, PK, Newgard, CB, Fletterick, RJ	Crit Rev Biochem Mol Biol	1989