Acidification of Tf:TfR1 containing endosome

Stable Identifier
R-HSA-917841
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endosome membrane
ReviewStatus
5/5
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Acidification of Tf:TfR1 containing endosome
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The function of V-type proton pumping ATPases is basically the same as that of F-type ATPases, except that V-ATPases cannot synthesize ATP from the proton motive force, the reverse reaction of pumping. When pumping, ATP hydrolysis drives a 120 degree rotation of the rotor which leads to movement of three protons into the phagosome (Adachi et al. 2007).
Literature References
PubMed ID Title Journal Year
17662945 Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation

Adachi, K, Oiwa, K, Nishizaka, T, Furuike, S, Noji, H, Itoh, H, Yoshida, M, Kinosita K, Jr

Cell 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

proton transmembrane transporter activity of V-ATPase:ATP6AP1 [endosome membrane]

Physical Entity
V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
Activity
proton transmembrane transporter activity (GO:0015078)
Orthologous Events
Acidification of Tf:TfR1 containing endosome (Bos taurus)
Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
Acidification of Tf:TfR1 containing endosome (Canis familiaris)
Acidification of Tf:TfR1 containing endosome (Danio rerio)
Acidification of Tf:TfR1 containing endosome (Dictyostelium discoideum)
Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
Acidification of Tf:TfR1 containing endosome (Gallus gallus)
Acidification of Tf:TfR1 containing endosome (Mus musculus)
Acidification of Tf:TfR1 containing endosome (Plasmodium falciparum)
Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
Acidification of Tf:TfR1 containing endosome (Saccharomyces cerevisiae)
Acidification of Tf:TfR1 containing endosome (Schizosaccharomyces pombe)
Acidification of Tf:TfR1 containing endosome (Sus scrofa)
Acidification of Tf:TfR1 containing endosome (Xenopus tropicalis)
Authored
Stephan, R  (2010-07-13)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-07-30)
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