80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC

Stable Identifier
R-HSA-5333615
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex consisting of selenocysteinyl (Sec) transfer RNA (tRNA) for Sec (Sec-tRNASec), selenocysteine-specific elongation factor (EEFSEC) aka SelB, selenocysteine insertion sequence-binding protein 2 (SECISBP2) aka SBP2 and GTP interacts with the 80S ribosomal protein complex (80S:Met-tRNAi:mRNA). This triggers the hydrolysis of GTP (to GDP) by EEFSEC and delivery of Sec-tRNASec to the ribosomal A site. Before the Sec residue is inserted into the nascent polypeptide chain, EEFSEC:GDP is released. This reaction is inferred from events occurring in rats.

Literature References
PubMed ID Title Journal Year
15821744 Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes

Chavatte, L, Brown, BA, Driscoll, DM

Nat. Struct. Mol. Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created