ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region

Stable Identifier
R-HSA-9753284
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
ReviewStatus
5/5
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ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region
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The ATP-binding cassette sub-family C member transporters (ABCCs, aka multidrug resistance-associated proteins, MRPs) mediate the export of organic anions and drugs from cells. Induction of ABCC expression after APAP-induced liver failure may represent a compensatory mechanism of damaged hepatocytes to reduce accumulation of potentially toxic compounds. ABCC1, 4 and 5 are thought to efflux the cysteine- and mercapto-conjugates of paracetamol (APAP-Cys and APAP-Mer respectively) from hepatocytes (Barnes et al. 2007).
Literature References
PubMed ID Title Journal Year
17627974 Induction of hepatobiliary efflux transporters in acetaminophen-induced acute liver failure cases

Pruimboom-Brees, IM, Aleksunes, LM, Goedken, MJ, Barnes, SN, Cherrington, NJ, Jakowski, AB, Augustine, L, Scheffer, GL, Manautou, JE

Drug Metab Dispos 2007
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Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCC1,4,5 [plasma membrane]

Physical Entity
ABCC1,4,5 [plasma membrane] (Homo sapiens)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Orthologous Events
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Bos taurus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Caenorhabditis elegans)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Canis familiaris)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Danio rerio)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Dictyostelium discoideum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Drosophila melanogaster)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Gallus gallus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Mus musculus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Plasmodium falciparum)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Rattus norvegicus)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Saccharomyces cerevisiae)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Schizosaccharomyces pombe)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Sus scrofa)
ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region (Xenopus tropicalis)
Authored
Jassal, B  (2021-09-06)
Reviewed
Huddart, R  (2021-10-13)
Created
Jassal, B  (2021-09-06)
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