Reactome | trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly

trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly

Stable Identifier

R-HSA-432706

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, Golgi membrane

ReviewStatus

5/5

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trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly

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Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the lysosome vesicle. Here only 5 clathrin triskelions are represented, though in reality many more would be involved in sculpting an entire vesicle.

Literature References

PubMed ID	Title	Journal	Year
11994746	Regulated transport of the glucose transporter GLUT4. James, DE, Bryant, NJ, Govers, R	Nat Rev Mol Cell Biol	2002
10394364	Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography Roseman, AM, Pearse, BM, Smith, CJ, Musacchio, A, Kirchhausen, Tomas, Harrison, SC	Mol Cell	1999