The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).
Griffith, OW, Misra, I
Bailey, HH, Gipp, JJ, Mulcahy, RT
glutamate-cysteine ligase activity of GCL [cytosol]
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