GCL ligates L-Glu to L-Cys

Stable Identifier
R-HSA-174367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glutamate and cysteine combine
ReviewStatus
5/5
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GCL ligates L-Glu to L-Cys
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The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).

Literature References
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as an event of
Catalyst Activity

glutamate-cysteine ligase activity of GCL [cytosol]

Physical Entity
GCL [cytosol] (Homo sapiens)
Activity
glutamate-cysteine ligase activity (GO:0004357)
Orthologous Events
GCL ligates L-Glu to L-Cys (Bos taurus)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Danio rerio)
GCL ligates L-Glu to L-Cys (Drosophila melanogaster)
GCL ligates L-Glu to L-Cys (Mus musculus)
GCL ligates L-Glu to L-Cys (Rattus norvegicus)
GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)
GCL ligates L-Glu to L-Cys (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2006-02-17)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-17)
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