GCL ligates L-Glu to L-Cys

Stable Identifier
R-HSA-174367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glutamate and cysteine combine
ReviewStatus
5/5
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GCL ligates L-Glu to L-Cys
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).
Literature References
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Catalyst Activity

glutamate-cysteine ligase activity of GCL [cytosol]

Physical Entity
GCL [cytosol] (Homo sapiens)
Activity
glutamate-cysteine ligase activity (GO:0004357)
Orthologous Events
GCL ligates L-Glu to L-Cys (Bos taurus)
GCL ligates L-Glu to L-Cys (Caenorhabditis elegans)
GCL ligates L-Glu to L-Cys (Canis familiaris)
GCL ligates L-Glu to L-Cys (Drosophila melanogaster)
GCL ligates L-Glu to L-Cys (Mus musculus)
GCL ligates L-Glu to L-Cys (Rattus norvegicus)
GCL ligates L-Glu to L-Cys (Schizosaccharomyces pombe)
GCL ligates L-Glu to L-Cys (Sus scrofa)
GCL ligates L-Glu to L-Cys (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2006-02-17)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-17)
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