PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

Stable Identifier
Reaction [transition]
Homo sapiens
(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)
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Cytosolic purine nucleoside phosphorylase (PNP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). PNP deficiency in vivo is associated with accumulation of guanosine and deoxyguanosine and leads to immunodeficiency (Williams et al. 1987).

Literature References
PubMed ID Title Journal Year
3029074 A human purine nucleoside phosphorylase deficiency caused by a single base change

Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW

J Biol Chem 1987
6771276 Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides

Hutton, JJ, Wiginton, DA, Coleman, MS

J Biol Chem 1980
2104852 Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution

Cook, WJ, Habash, J, Greenhough, TJ, Babu, YS, Carter, DC, Parks, Jr, RE, Rule, SA, Bugg, CE, Stoeckler, JD, Chen, SF, Ealick, SE, Helliwell, JR

J Biol Chem 1990
Catalyst Activity

purine-nucleoside phosphorylase activity of PNP trimer [cytosol]

Orthologous Events
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