Cytosolic purine nucleoside phosphorylase (PNP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). PNP deficiency in vivo is associated with accumulation of guanosine and deoxyguanosine and leads to immunodeficiency (Williams et al. 1987).
Williams, SR, Gekeler, V, McIvor, RS, Martin, Jr, DW
Hutton, JJ, Wiginton, DA, Coleman, MS
Cook, WJ, Habash, J, Greenhough, TJ, Babu, YS, Carter, DC, Parks, Jr, RE, Rule, SA, Bugg, CE, Stoeckler, JD, Chen, SF, Ealick, SE, Helliwell, JR
purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
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