The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003).
Cooper, GM, Yao, R
DeClue, JE, McCormick, F, Zhang, K, Lowy, DR, Papageorge, AG, Vass, WC
GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane]
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