p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

Stable Identifier
R-HSA-4093339
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003).

Literature References
PubMed ID Title Journal Year
2201922 Suppression of c-ras transformation by GTPase-activating protein

Zhang, K, DeClue, JE, Vass, WC, Papageorge, AG, McCormick, F, Lowy, DR

Nature 1990
7478585 Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells

Yao, R, Cooper, GM

Oncogene 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created