Reactome | p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

Stable Identifier

R-HSA-4093339

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

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The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
2201922	Suppression of c-ras transformation by GTPase-activating protein Zhang, K, DeClue, JE, Vass, WC, Papageorge, AG, McCormick, F, Lowy, DR	Nature	1990
7478585	Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells Yao, R, Cooper, GM	Oncogene	1995