p120-RasGAP activates GTP hydrolysis on RAS, inactivating it

Stable Identifier
R-HSA-4093339
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003).
Literature References
PubMed ID Title Journal Year
7478585 Regulation of the Ras signaling pathway by GTPase-activating protein in PC12 cells

Yao, R, Cooper, GM

Oncogene 1995
2201922 Suppression of c-ras transformation by GTPase-activating protein

Zhang, K, DeClue, JE, Vass, WC, Papageorge, AG, McCormick, F, Lowy, DR

Nature 1990
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Catalyst Activity

GTPase activator activity of p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane]

Physical Entity
p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Homo sapiens)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Bos taurus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Caenorhabditis elegans)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Danio rerio)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Drosophila melanogaster)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Gallus gallus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Mus musculus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Rattus norvegicus)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Sus scrofa)
p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-08-14)
Cite Us!