The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003).
Zhang, K, DeClue, JE, Vass, WC, Papageorge, AG, McCormick, F, Lowy, DR
Yao, R, Cooper, GM
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