Reactome | FPGS-2 transforms THF to THFPG

FPGS-2 transforms THF to THFPG

Stable Identifier

R-HSA-197958

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Conversion of cytosolic THF to THF-polyglutamate

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic folylpolyglutamate synthase catalyzes the reaction of THF-glutamate(n), L-glutamate, and ATP to form THF-glutamate(n+1), ADP, and orthophosphate. (The first glutamate residue is attached to the glutamate moiety of THF itself; for convenience the process is annotated here as if it proceeded in a single concerted step.) The extent of conjugation is variable, but the commonest cytosolic form of THF has five added glutamate residues. Although its properties as a donor of one-carbon units are not affected by glutamate addition, THF that lacks added glutamate residues cannot be retained in the cytosol so this reaction is needed for normal THF function under physiological conditions (Garrow et al. 1992; Chen et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
1409616	Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure Shane, B, Garrow, TA, Admon, A	Proc Natl Acad Sci U S A	1992
8662720	Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene Korenberg, J, Shane, B, Qi, H, Garrow, TA, Choi, YJ, Chen, L	J Biol Chem	1996