NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP

Stable Identifier
R-HSA-2395873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8-oxo-GDP + H2O => 8-oxo-GMP + Pi
ReviewStatus
5/5
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NUDT18 (MTH3) catalyzes the reaction of 8-oxo-GDP and water to form 8-oxo-GMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.
Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D, Kamiya, H

J. Biol. Chem. 2012
Participants
Participates
Catalyst Activity

8-oxo-GDP phosphatase activity of NUDT18-1 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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