NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP

Stable Identifier
R-HSA-2395873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
8-oxo-GDP + H2O => 8-oxo-GMP + Pi
ReviewStatus
5/5
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NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP
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NUDT18 (MTH3) catalyzes the reaction of 8-oxo-GDP and water to form 8-oxo-GMP and Pi (orthophosphate) (Takagi et al. 2012). The subcellular location of NUDT18 has not been established but is assumed to be cytosolic like NUDT1.

Literature References
PubMed ID Title Journal Year
22556419 Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates: COMPARISON WITH MTH1 AND MTH2

Takagi, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D, Kamiya, H

J. Biol. Chem. 2012
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Catalyst Activity

8-oxo-GDP phosphatase activity of NUDT18-1 [cytosol]

Physical Entity
NUDT18-1 [cytosol] (Homo sapiens)
Activity
8-oxo-GDP phosphatase activity (GO:0044716)
Orthologous Events
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Bos taurus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Caenorhabditis elegans)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Canis familiaris)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Danio rerio)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Drosophila melanogaster)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Mus musculus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Rattus norvegicus)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Sus scrofa)
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2012-07-06)
Reviewed
Ito, R  (2012-10-05)
Created
D'Eustachio, P  (2012-07-03)
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