TBC RabGAPs accelerate GTP hydrolysis by RAB35

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RAB35 is a Rab protein with both plasma membrane and endosomal membrane localization, where it controls vesicular trafficking. RAB35 regulates the endocytic recycling of numerous protein cargoes, is involved in the recycling of synaptic vesicles (Uytterhoeven et al. 2011; Allaire et al. 2010, Sato et al. 2008, Sheehan et al. 2106, Klinkert & Echard 2016), controls the fusion of exosomes (Hsu et al. 2010), and regulates the actin cytoskeleton (Zhang et al. 2009). At least five different members of the TBC protein family are GAPs for Rab35. The three members of TBC1D10A-C family (also known as EPI64A-C) are identified to have Rab35-specific GAP activity and regulate exosome secretion (Hsu et al. 2010). TBC1D10 family members are also involved in the endocytic recycling and prevent cytokinesis (Kouranti et al. 2006, Chesneau et al. 2012).
TBC1D13 was identified as a specific GAP for Rab35 and observed to act as a potent inhibitor of insulin-stimulated GLUT4 translocation (Davey et al. 2012). TBC1D24 is a homolog of a Drosophila protein called skywalker, which has been shown to exhibit GAP activity towards Rab35 (Uytterhoeven et al. 2011).
Literature References
PubMed ID Title Journal Year
21458671 Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins

Miskiewicz, K, Kuenen, S, Verstreken, P, Kasprowicz, J, Uytterhoeven, V

Cell 2011
22762500 TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes

Stöckli, J, James, DE, Davey, JR, Lambright, DG, Mishra, AK, Junutula, JR, Humphrey, SJ

Traffic 2012
20404108 Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C

Lauterbach, MA, Manrique-Hoyos, N, Barr, FA, Simons, M, Hsu, C, Jung, S, Morohashi, Y, Bakhti, M, Yoshimura, S, Rhee, J, Möbius, W, Grønborg, M

J. Cell Biol. 2010
Catalyst Activity

GTPase activity of RAB35:GTP [clathrin-coated endocytic vesicle membrane]

This event is regulated
Orthologous Events
Cite Us!