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GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
Stable Identifier
R-HSA-141673
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Please note that this reaction was inferred from experiments performed using Saccharomyces cerevisiae.
Literature References
PubMed ID
Title
Journal
Year
10358005
The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.
Katada, T
,
Kobayashi, T
,
Hoshino, S
,
Imai, M
,
Uchida, N
J Biol Chem
1999
Participants
Input
H2O [cytosol]
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol]
(Homo sapiens)
Output
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol]
(Homo sapiens)
Pi [cytosol]
Participates
as an event of
Eukaryotic Translation Termination (Homo sapiens)
Event Information
Go Biological Process
translational termination (0006415)
Inferred From
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Saccharomyces cerevisiae)
Authored
Gillespie, ME (2005-01-27)
Created
Bedwell, DM (2005-01-03)
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