Translocation of antigenic peptides back to phagosomes via TAP

Stable Identifier
R-HSA-1236949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol, phagocytic vesicle
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Translocation of antigenic peptides back to phagosomes via TAP
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After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.

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hasEvent
Catalyst Activity
Catalyst Activity
Title
ATPase-coupled peptide antigen transmembrane transporter activity of TAP [phagocytic vesicle membrane]
Physical Entity
TAP [phagocytic vesicle membrane]
Activity
ATPase-coupled peptide antigen transmembrane transporter activity (0015433)
Inferred From
Translocation of antigenic peptides back to phagosomes via TAP (Gallus gallus)
Authored
Garapati, P V  (2011-03-28)
Reviewed
Desjardins, M  (2011-05-13)
English, L  (2011-05-13)
Created
Garapati, P V  (2011-03-28)