Translocation of antigenic peptides back to phagosomes via TAP

Stable Identifier
R-HSA-1236949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol, phagocytic vesicle
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Translocation of antigenic peptides back to phagosomes via TAP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ABC-type peptide antigen transporter activity of TAP [phagocytic vesicle membrane]

Physical Entity
TAP [phagocytic vesicle membrane] (Homo sapiens)
Activity
ABC-type peptide antigen transporter activity (GO:0015433)
Inferred From
Translocation of antigenic peptides back to phagosomes via TAP (Gallus gallus)
Authored
Garapati, P V  (2011-03-28)
Reviewed
English, L  (2011-05-13)
Desjardins, M  (2011-05-13)
Created
Garapati, P V  (2011-03-28)
Cite Us!