Translocation of antigenic peptides back to phagosomes via TAP

Stable Identifier
R-HSA-1236949
Type
Reaction
Species
Homo sapiens
Compartment
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After processing by the proteasome, some of the oligopeptides could be reinternalized to the phagosome lumen of the same phagosome through the TAP complex probably acquired during ER-phagosome fusion. Guermonprez et al. (2003) tested this model and observed abundant TAP complex in early phagosomes and its reduction over time. Electron microscopy analysis of purified phagosomes also showed the insertion of TAP2 into the phagosomal membrane.

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Participates
Catalyst Activity

ABC-type peptide antigen transporter activity of TAP [phagocytic vesicle membrane]

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