Reactome | thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

Stable Identifier

R-HSA-112266

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

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Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1590793	Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Waltenberger, J, Miyazono, K, Usuki, K, Saras, J, Heldin, CH, Pierce, G, Thomason, A	Biochem Biophys Res Commun	1992
7284378	Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase Bricaud, H, Desgranges, C, Rabaud, M, Razaka, G	Biochim Biophys Acta	1981
14725767	Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor McCall, EJ, Colls, JG, Timms, D, McAlister, MS, Barry, ST, Tucker, JA, Ernill, RJ, Norman, RA, Minshull, CA, McMiken, HH, Breed, J, Paterson, DS, Bate, M, Luke, RW, Pauptit, RA	Structure	2004