thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

Stable Identifier
Homo sapiens
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Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Literature References
PubMed ID Title Journal Year
1590793 Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.

Waltenberger, J, Miyazono, K, Usuki, K, Saras, J, Heldin, CH, Pierce, G, Thomason, A

Biochem Biophys Res Commun 1992
7284378 Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase

Bricaud, H, Desgranges, C, Rabaud, M, Razaka, G

Biochim Biophys Acta 1981
14725767 Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor

McCall, EJ, Colls, JG, Timms, D, McAlister, MS, Barry, ST, Tucker, JA, Ernill, RJ, Norman, RA, Minshull, CA, McMiken, HH, Breed, J, Paterson, DS, Bate, M, Luke, RW, Pauptit, RA

Structure 2004
Event Information
Catalyst Activity

pentosyltransferase activity of TYMP dimer [cytosol]

Orthologous Events
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