thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic thymidine phosphorylase (TYMP) catalyzes the reversible reactions of thymine or uracil with 2-deoxy-D-ribose 1-phosphate to form thymidine or deoxyuridine and orthiophosphate. The active form of the enzyme is a homodimer (Desgranges et al. 1981; Norman et al. 2004; Usuki et al. 1992).

Literature References
PubMed ID Title Journal Year
7284378 Catabolism of thymidine in human blood platelets: purification and properties of thymidine phosphorylase

Desgranges, C, Razaka, G, Rabaud, M, Bricaud, H

Biochim Biophys Acta 1981
1590793 Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.

Usuki, K, Saras, J, Waltenberger, J, Miyazono, K, Pierce, G, Thomason, A, Heldin, CH

Biochem Biophys Res Commun 1992
14725767 Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor

Norman, RA, Barry, ST, Bate, M, Breed, J, Colls, JG, Ernill, RJ, Luke, RW, Minshull, CA, McAlister, MS, McCall, EJ, McMiken, HH, Paterson, DS, Timms, D, Tucker, JA, Pauptit, RA

Structure 2004
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
transferase activity, transferring pentosyl groups of TYMP dimer [cytosol]
Physical Entity
Orthologous Events
Cite Us!