RHOG GAPs stimulate RHOG GTPase activity

Stable Identifier
R-HSA-9014434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following GTPase activating proteins (GAPs) were shown to bind RHOG and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHO:GTP complex into the inactive RHO:GDP complex:
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020 by showing binding of ARHGAP35 to the constitutively active RHOG mutant)

The following GAPs were shown to bind RHOG and stimulate its GTPase activity in some but not all studies or were only shown to bind to constitutively active RHOG mutant without testing for the activation of the RHOG GTPase activity and are annotated as candidate RHOG GAPs:
ARHGAP1 (Amin et al. 2016: RHOG directed GAP activity; Bagci et al. 2020: no binding to active RHOG)
ARHGAP5 (Bagci et al. 2020: binding to active RHOG)
ARHGAP21 (Bagci et al. 2020: binding to active RHOG)
ARHGAP32 (Bagci et al. 2020: binding to active RHOG)
ARHGAP39 (Bagci et al. 2020: binding to active RHOG)
DEPDC1B (Bagci et al. 2020: binding to active RHOG)
OPHN1 (Amin et al. 2016: RHOG directed GAP activity; Bagci et al. 2020: no binding to active RHOG)
PIK3R1 (Bagci et al. 2020: binding to active RHOG)

The following GAPs were shown to either not act on RHOG or to not bind the constitutively active RHOG mutant in the high throughput screen by Bagci et al. 2020:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP11B (Florio et al. 2015)
ARHGAP12 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP36 (Rack et al. 2014)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OCRL (Erdmann et al. 2007; Lichter Konecki et al. 2006; Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)
SYDE1 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
27481945 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

Amin, E, Jaiswal, M, Derewenda, U, Reis, K, Nouri, K, Koessmeier, KT, Aspenström, P, Somlyo, AV, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2016
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Catalyst Activity

GTPase activator activity of RHOG GAPs [cytosol]

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