Reactome | PGAM5 dodecamer dephosphorylates p-S336-ME1

PGAM5 dodecamer dephosphorylates p-S336-ME1

Stable Identifier

R-HSA-9861725

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

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PGAM5 dodecamer dephosphorylates p-S336-ME1

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Serine/threonine-protein phosphatase PGAM5 (aka phosphoglycerate mutase family member 5), localized on the outer mitochondrial membrane, dephosphorylates cytosolic p-S336-ME1, restoring its catalytic activity (Lo & Hannink, 2008; Zhu et al., 2020). PGAM5 forms tubular filaments composed of stacked dodecameric rings which are essential for PGAM5 catalysis (Ruiz et al., 2019).

Literature References

PubMed ID	Title	Journal	Year
18387606	PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria Lo, SC, Hannink, M	Exp Cell Res	2008
30705304	Functional role of PGAM5 multimeric assemblies and their polymerization into filaments Ruiz, K, Thaker, TM, Agnew, C, Miller-Vedam, L, Trenker, R, Herrera, C, Ingaramo, M, Toso, D, Frost, A, Jura, N	Nat Commun	2019
31735643	Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis Zhu, Y, Gu, L, Lin, X, Liu, C, Lu, B, Cui, K, Zhou, F, Zhao, Q, Prochownik, EV, Fan, C, Li, Y	Mol Cell	2020