ULK1 is dephosphorylated

Stable Identifier
R-HSA-5683925
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Under starvation conditions ULK1 undergoes dephosphorylation, particularly at serine-639 and serine-758 (Shang et al. 2011). The S757 unphosphorylated ULK1 is able to associate with, and be activated by, AMPK (Egan et al. 2011). The protein phosphatase(s) involved in ULK1 dephosphorylation are currently unknown (Wong et al. 2013).

Literature References
PubMed ID Title Journal Year
21383122 Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Shang, L, Chen, S, Du, F, Li, S, Zhao, L, Wang, X

Proc. Natl. Acad. Sci. U.S.A. 2011
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created