ULK1 is dephosphorylated

Stable Identifier
R-HSA-5683925
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ULK1 is dephosphorylated
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Under starvation conditions ULK1 undergoes dephosphorylation, particularly at serine-639 and serine-758 (Shang et al. 2011). The S757 unphosphorylated ULK1 is able to associate with, and be activated by, AMPK (Egan et al. 2011). The protein phosphatase(s) involved in ULK1 dephosphorylation are currently unknown (Wong et al. 2013).
Literature References
PubMed ID Title Journal Year
21383122 Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Wang, X, Shang, L, Li, S, Du, F, Zhao, L, Chen, S

Proc. Natl. Acad. Sci. U.S.A. 2011
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Orthologous Events
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ULK1 is dephosphorylated (Drosophila melanogaster)
ULK1 is dephosphorylated (Gallus gallus)
ULK1 is dephosphorylated (Mus musculus)
ULK1 is dephosphorylated (Rattus norvegicus)
ULK1 is dephosphorylated (Saccharomyces cerevisiae)
ULK1 is dephosphorylated (Schizosaccharomyces pombe)
ULK1 is dephosphorylated (Sus scrofa)
ULK1 is dephosphorylated (Xenopus tropicalis)
Authored
Jupe, S  (2015-02-02)
Reviewed
Klionsky, DJ  (2015-09-03)
Tooze, SA  (2015-05-13)
Created
Jupe, S  (2015-03-17)
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