Dephosphorylation of pL1 (Y1176)

Stable Identifier
R-HSA-445089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dephosphorylation of pL1 (Y1176)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
L1 translocated to the non raft membranes of the C-domain is dephosphorylated. A number of potential candidate phosphatases exist including phosphotyrosine phosphatases. Dephosphorylation of Y1176 allows L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.
Literature References
PubMed ID Title Journal Year
12082080 L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1

Landreth, G, Rapoport, I, Kamei, Y, Schaefer, AW, Beach, CM, Lemmon, SK, Kamiguchi, H, Lemmon, V, Kirchhausen, Tomas, Wong, EV

J Cell Biol 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of unknown protein [cytosol]

Physical Entity
unknown protein [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
Cite Us!