Dephosphorylation of pL1 (Y1176)

Stable Identifier
R-HSA-445089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Dephosphorylation of pL1 (Y1176)
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L1 translocated to the non raft membranes of the C-domain is dephosphorylated. A number of potential candidate phosphatases exist including phosphotyrosine phosphatases. Dephosphorylation of Y1176 allows L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.

Literature References
PubMed ID Title Journal Year
12082080 L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1

Landreth, G, Rapoport, I, Kamei, Y, Schaefer, AW, Beach, CM, Lemmon, SK, Kamiguchi, H, Lemmon, V, Kirchhausen, Tomas, Wong, EV

J Cell Biol 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of unknown protein [cytosol]

Physical Entity
unknown protein [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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